The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

bioRxiv · Jun 2, 2023 · PreprintImmunology

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

P. Canales-Herrerias, M. Uzzan, A. Seki, R. S. Czepielewski, B. Verstockt, A. Livanos, F. Raso, A. Dunn, D. Dai, A. Wang, Z. Al-taie, J. Martin, H. M. Ko, M. Tokuyama, M. Tankelevich, , S. Mehandru

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

bioRxiv · Jan 19, 2023Immunology

Evolution of Antibody Immunity to SARS-CoV-2

C. Gaebler, Z. Wang, J. C. C. Lorenzi, F. Muecksch, S. Finkin, M. Tokuyama, A. Cho, M. Jankovic, D. Schaefer-Babajew, T. Y. Oliveira, M. Cipolla, C. Viant, C. O. Barnes, A. Hurley, M. Turroja, , R. Patel

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

bioRxiv · Nov 3, 2020Immunology

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

M. Suarez-Farinas, M. Tokuyama, G. Wei, R. Huang, A. Livanos, D. Jha, A. Levescot, H. Irizar, R. Kosoy, S. Cording, W. Wang, H. Irizar, R. Ungaro, A. Di Narzo, G. Martinez-Delgado, , S. Mehandru

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

bioRxiv · May 21, 2020Immunology