M. Schilling

Phototropin connects blue light perception to starch metabolism in green algae

The paper identifies a blue light signaling pathway in green algae that inhibits starch accumulation via PMSK1 dephosphorylation and GAP1 repression.

Cooperative dynamics of DNA grafted magnetic nanoparticles optimize magnetic biosensing and coupling to DNA origami

This study shows that DNA grafting density on magnetic nanoparticles affects their dynamics and biosensing performance, with optimal sensitivity at intermediate densities.

Hypoxia dampens innate immune signalling at early time points and increases Zika virus replication in iPSC-derived macrophages

This study shows that hypoxia reduces interferon-stimulated gene expression and increases Zika virus replication in iPSC-derived macrophages.

Amplification and extraction free quantitative detection of viral nucleic acids and single-base mismatches using magnetic signal amplification circuit

This paper introduces a magnetic signal amplification circuit for detecting viral nucleic acids and single-base mismatches without amplification or extraction, achieving higher sensitivity than existing methods.

Circadian regulation of human immunodeficiency virus type 1 replication

This study shows HIV-1 replication is regulated by circadian rhythms through interactions between transcription factors BMAL1, REV-ERB, and ROR, with implications for HIV therapy.

Heavy metal pollution impacts soil bacterial community structure and antimicrobial resistance at the Birmingham 35th Avenue Superfund Site

This study examines how heavy metal pollution affects soil bacterial communities and antimicrobial resistance at a Superfund site, finding reduced diversity and increased AMR gene prevalence in contaminated soils.

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

This study shows BMAL1 regulates ACE2 expression and SARS-CoV-2 entry in lung epithelial cells, with SR9009 reducing viral replication through circadian mechanisms.

Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication

This study shows that REV-ERB agonists inhibit HIV-1 replication by suppressing its promoter activity in multiple cell types.

Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.

Decentralized Control of Insect Walking - a simple neural network explains a wide range of behavioral and neurophysiological results

This paper introduces a decentralized neural network controller for insect walking, demonstrating adaptive behavior in various environments without relying on CPG-like structures.