Author

T. Siggers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:non-human primate· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

L. M. Williams· 2 shared T. D. Gilmore· 2 shared A. Addanki· 1 shared A. B. Chang· 1 shared A. Bagdasaryants· 1 shared A. Bonilla· 1 shared A. Browne· 1 shared A. Cyr· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

L. M. Williams

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution

A. E. Daly, A. B. Chang, P. Purbey, K. J. Williams, G. Yeh, S. Li, S. D. Pope, B. Venkatesh, B. D. Redelings, S. Li, K. Nguyen, J. Rodriguez, K. Jorgensen, T. Siggers, L. Chen, S. T. Smale

The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.

Nature Immunology · Apr 30, 2025Peer-reviewedImmunology

Widespread perturbation of ETS factor binding sites in cancer

S. C. Pro, H. Hook, D. Bray, D. Berenzy, D. Moyer, M. Yin, A. T. Labadorf, R. Tewhey, T. Siggers, J. I. F. Bass

The paper identifies 2,555 driver non-coding variants in cancer promoters using a TF-aware burden test, showing widespread disruption of ETS factor binding.

bioRxiv · Aug 10, 2022Cancer Biology

Diversification of Transcription Factor NF-κB in Protists

L. M. Williams, S. Sridhar, J. Samaroo, E. K. Adindu, A. Addanki, BB522 Molecular Biology Laboratory, P. J. Aguirre Carrion, C. J. DiRusso, N. Rodriguez-Sastre, T. Siggers, T. D. Gilmore

This paper functionally characterizes NF-κB in protists, showing its structural and regulatory diversity and evolutionary origins outside of metazoans.

bioRxiv · Mar 15, 2021Cell Biology

Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation

L. M. Williams, M. M. Inge, K. M. Mansfield, A. Rasmussen, J. Afghani, M. Agrba, C. Albert, C. Andersson, M. Babaei, M. Babaei, A. Bagdasaryants, A. Bonilla, A. Browne, S. Carpenter, T. Chen, , T. D. Gilmore

This study characterizes the NF-κB protein in the sponge Amphimedon queenslandica, showing conserved features with vertebrates but distinct regulatory mechanisms.

bioRxiv · Aug 6, 2019Cell Biology