Stepwise neofunctionalization of the NF-κB family member c-Rel during vertebrate evolution
A. E. Daly, A. B. Chang, P. Purbey, K. J. Williams, G. Yeh, S. Li, S. D. Pope, B. Venkatesh, B. D. Redelings, S. Li, K. Nguyen, J. Rodriguez, K. Jorgensen, T. Siggers, L. Chen, S. T. Smale
The paper shows c-Rel, an NF-κB family member, evolved unique DNA-binding properties in mammals, enhancing its ability to regulate Il12b and support immune complexity.
Nature Immunology · Apr 30, 2025Peer-reviewedImmunology