Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain
C. Chen, H.-W. Yi, Y. Zhang, T. Wang, T.-Y. Gao, Z.-L. Lou, T.-F. Wei, Y.-B. Lu, T.-T. Li, W.-P. Zhang, C. Tang
This study shows that phosphorylated ubiquitin (pUb) increases with age and contributes to neurodegeneration by impairing proteasomal function and accelerating protein aggregation.
bioRxiv · Aug 10, 2023 · PreprintCell Biology