Author

H.-W. Yi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Tang· 2 shared W.-P. Zhang· 2 shared C. Chen· 1 shared J. Yang· 1 shared K. Liu· 1 shared T. Wang· 1 shared T.-F. Wei· 1 shared T.-T. Li· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

C. Tang

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2 papers

Recent·Most cited

Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain

C. Chen, H.-W. Yi, Y. Zhang, T. Wang, T.-Y. Gao, Z.-L. Lou, T.-F. Wei, Y.-B. Lu, T.-T. Li, W.-P. Zhang, C. Tang

This study shows that phosphorylated ubiquitin (pUb) increases with age and contributes to neurodegeneration by impairing proteasomal function and accelerating protein aggregation.

bioRxiv · Aug 10, 2023 · PreprintCell Biology

Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13

Z. Liu, X. Dong, H.-W. Yi, J. Yang, Z. Gong, Y. Wang, K. Liu, W.-P. Zhang, C. Tang

This paper determines the structural basis of how Rpn13 recognizes K48-linked Ub chains through a bivalent interaction, revealing a mechanism for proteasomal selectivity.

bioRxiv · Jan 29, 2019Biophysics