Cell BiologybioRxivPreprint
Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain
C. Chen, H.-W. Yi, Y. Zhang…·C. Tang
This study shows that phosphorylated ubiquitin (pUb) increases with age and contributes to neurodegeneration by impairing proteasomal function and accelerating protein aggregation.
DOI 10.1101/2023.08.10.552882