A. Rojas

Assessing mechanisms driving phenol isopropylated phosphate (IPP)- induced larval photomotor response deficits in zebrafish

This study investigates IPP-induced developmental toxicity in zebrafish embryos, finding morphological abnormalities and disrupted larval photomotor responses linked to DNA hypermethylation and gene expression changes in the brain and eye.

Quantification of rose rosette emaravirus (RRV) titers in eriophyoid mites: insights into viral dynamics and vector competency

This study quantifies RRV titers in eriophyoid mites using qRT-PCR, revealing active replication in P. fructiphilus and no replication in P. adalius.

Flame retardant tetrabromobisphenol A (TBBPA) disrupts histone acetylation during zebrafish maternal-to-zygotic transition

This study shows TBBPA exposure disrupts zebrafish early development by inhibiting histone acetylation during zygotic genome activation.

A natural history of networks: Modeling higher-order interactions in geohistorical data

This paper introduces higher-order network models to analyze geohistorical data, addressing limitations of standard network approaches and improving the representation of complex relational structures in paleobiology.

Mendelian Randomization Analysis of the Relationship Between Native American Ancestry and Gallbladder Cancer Risk

The paper uses Mendelian randomization to find a causal link between Mapuche ancestry and gallbladder cancer risk, with gallstone disease as a mediator.

LRH-1/NR5A2 regulates the PTGS2-PGE2-PTGER1 signalling axis contributing to islet survival and antidiabetic actions of the agonist BL001

This study identifies BL001's mechanism of action through LRH-1/NR5A2 activation, showing it protects beta cells via the PTGS2-PGE2-PTGER1 signalling pathway.

Prediction and validation of the three-dimensional structure of glucokinase-1 from Phytophthora infestans

The paper predicts and validates the 3D structure of PiGlcK-1 from Phytophthora infestans using in silico tools and identifies potential ligand-binding regions.

OCCURRENCE OF THE BRACHIOPOD TICHOSINA IN DEEP-SEA CORAL BOTTOMS OF THE CARIBBEAN SEA AND ITS PALEOENVIRONMENTAL IMPLICATIONS

The paper investigates the ecological relationship between the brachiopod Tichosina and deep-water corals in the Caribbean, suggesting historical links dating back to the Pliocene.

A multiscale view of the Phanerozoic fossil record reveals the three major biotic transitions

The paper analyzes the Phanerozoic fossil record to identify three major biotic transitions by revealing four global benthic mega-assemblages and their shifts in dominance.

Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

This study shows that genetic background strain influences aortic fibrosis in hypertensive mice, with C57BL/6J mice showing more maladaptive remodeling than 129SvEv mice.

Genetic diversity of the spinach downy mildew pathogen based on hierarchical sampling

The paper analyzes genetic diversity in the spinach downy mildew pathogen Peronospora effusa using SNP loci from 67 isolates, revealing clonal and sexual reproduction strategies and population substructure.

The proteasomal deubiquitinating enzyme PSMD14 regulates macroautophagy by controlling Golgi-to-ER retrograde transport

The paper identifies PSMD14 as a regulator of Golgi-to-ER retrograde transport and macroautophagy through its role in K63-Ub chain deubiquitination.

Regularities in species niches reveal the World's climatic regions

The paper identifies 16 global climatic regions based on species niches, consistent across animal groups and plant classifications, highlighting climatic restrictions for life.

Evolutionary footprints reveal insights into plant microRNA biogenesis

The paper analyzes plant microRNA precursors to identify evolutionary footprints that reveal structural determinants in miRNA biogenesis.