L. Nieman

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors

This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.

Single cell proteomics of tumor compartments identifies differential kinase activities defining sensitivity to mTOR-PI3-kinase inhibition

The paper uses single cell proteomics to identify kinase activity differences in tumor compartments, showing how they affect sensitivity to mTOR-PI3K inhibition.