V. H. Wysocki

The paper introduces a method to design pseudosymmetric protein hetero-oligomers by redesigning symmetric homo-oligomers and recombining them to form new hetero-oligomers with high structural specificity.

The paper assesses the oligomeric states of 17 bacterial proteins using multiple techniques, finding that most exist in multiple forms and that AlphaFold Multimer better predicts their quaternary structures than existing databases.

The paper quantifies thermodynamic coupling between ligand binding sites in homo-oligomeric proteins using statistical models and native mass spectrometry, revealing large differences in cooperativity.

This paper determines the structure of a bacteriophage RecT homolog bound to a novel DNA duplex intermediate, revealing insights into DNA annealing mechanisms.

This study shows that ion mobility mass spectrometry data improve protein structure prediction using Rosetta, achieving better accuracy for 15 out of 23 benchmark proteins.

This study shows that HIV-1 Gag and Gag{Delta}p6 specifically dimerize on Psi RNA, supporting a p6-independent mechanism for viral particle assembly initiation.