V. Serra

Evaluation of homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional tissue-based immunofluorescence assays

This study evaluates homologous recombination repair status in metastatic prostate cancer using next-generation sequencing and RAD51 immunofluorescence assays, finding strong correlation between genomic and functional HRR loss.

Interpretable Inflammation Landscape of Circulating Immune cells

This paper constructs a single-cell atlas of circulating immune cells to understand inflammation across diseases and develops a classifier for inflammatory diseases.

Host association and intracellularity evolved multiple times independently in the Rickettsiales

The paper investigates the evolution of host association and intracellularity in Rickettsiales by analyzing genomic data and functional reconstructions, finding that these traits evolved multiple times independently.

Ciliated protozoa from industrial WWTP activated sludge: a biodiversity survey including trophic interactions and redescription of Bakuella subtropica (Spirotrichea, Hypotrichia) according to Next Generation Taxonomy

The paper characterizes ciliate communities in a wastewater treatment plant, identifies trophic interactions, and redescribes a species using modern taxonomy.

Personalized Cancer Therapy Prioritization Based on Driver Alteration Co-occurrence Patterns

The paper identifies actionable genomic vulnerabilities in cancer by analyzing driver alteration co-occurrence patterns and validates predictions in mice, improving drug response modeling from patient data.

Cyclin E1 protein is stabilized in BRCA1 mutated breast cancers leading to synergy between CDK2 and PARP inhibitors

The paper identifies cyclin E1 stabilization in BRCA1-mutated breast cancers and shows synergy between CDK2 and PARP inhibitors in treating these cancers.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

Next generation taxonomy: integrating traditional species description with the holobiont concept and genomic approaches - The in-depth characterization of a novel Euplotes species as a case study

The paper introduces a new taxonomy framework integrating holobiont concepts and genomic analysis, exemplified by describing a novel Euplotes species and its symbiont.