Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics
K. Tsai, V. Stojkovic, D. J. Lee, I. D. Young, T. Szal, N. Vazquez-Laslop, A. S. Mankin, J. S. Fraser, D. Galonic Fujimori
This study determines cryo-EM structures of oxazolidinone antibiotics bound to stalled ribosomes, revealing how alanine at the penultimate position enables context-specific inhibition.
bioRxiv · Aug 10, 2021Biophysics