CDH1 loss defines distinct diffuse-gastric cancer subtype with T cell exhaustion and EZH2 regulon activation
G. Zou, Y. Huang, S. Zhang, K.-P. Ko, B. J. Kim, J. Zhang, V. Venkatesan, M. P. Pizzi, S. Jun, N. Niu, H. Wang, S. Song, J. A. Ajani, J.-I. Park
This study identifies two distinct subtypes of diffuse-type gastric cancer associated with CDH1 loss, highlighting T cell exhaustion and EZH2 regulon activation.
bioRxiv · Mar 23, 2023Cancer Biology