V. Vykunta

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

This study identifies the molecular mechanisms by which particulate antigens induce potent B cell responses, showing signal amplification and reduced proliferation thresholds independent of T cell help and BCR avidity.

A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two

This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.