Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection
M. N. Vu, R. E. Alvarado, D. R. Morris…·V. D. Menachery
This study identifies the N679K mutation in Omicron variants as reducing spike protein expression and attenuating SARS-CoV-2 infection, while showing a replication advantage in the upper airway.