Z. Su

Lymphoid origin of a lineage of intrinsically activated plasmacytoid dendritic cell in mice and humans

The paper identifies a novel plasmacytoid dendritic cell lineage in mice and humans derived from common lymphoid progenitors, characterized by unique gene expression and functional properties.

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

This study shows SASH1 reduces melanin synthesis and metastasis by suppressing TGF-β1 signaling through regulation of THBS1 in melanocytes.

Monocytic fibrocyte-like cell enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity

The paper identifies fibrocyte-like cells as key drivers of nucleus pulposus fibrosis in disc degeneration, showing their role in myofibroblast formation and disease severity.

Metabolic interactions of a minimal bacterial consortium drive robust nitritation at acidic pH

This study identifies a minimal bacterial consortium that efficiently drives nitritation at acidic pH through metabolic interactions and stress adaptation mechanisms.

Ambient Temperature Bacterial Large Ribosomal Subunit Structure Enabled by Serial Femtosecond X-ray Crystallography

This study determines the structure of the 50S ribosomal subunit from Thermus thermophilus at ambient temperature using serial femtosecond X-ray crystallography, revealing new dynamics and antibiotic binding sites.

Evolution of wheat blast resistance gene Rmg8 accompanied by differentiation of variants recognizing the powdery mildew fungus

The paper traces the evolutionary origin of wheat blast resistance gene Rmg8 and shows its ability to recognize both wheat blast and powdery mildew pathogens.

Manipulation of Bacterial ROS Production Leads to Self-escalating DNA Damage and Resistance-resistant Lethality for Intracellular Mycobacteria

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

Understanding the General Principles of T Cell Engagement by Multiscale Computational Simulations

This study uses multiscale computational simulations to model T cell engagement by bispecific antibodies, identifying strategies to enhance efficacy and reduce off-target effects.

Structural basis for functional properties of cytochrome c oxidase

This study reveals the structural differences between the oxidized O state and the metastable OH state of cytochrome c oxidase using spectroscopy and crystallography, showing how Y244's protonation state affects proton translocation.

Real-Time Quantification of Cell Mechanics and Functions by Double Resonator Piezoelectric Cytometry -Theory and Study of Cellular Adhesion of HUVECs

This paper introduces DRPC to measure cell-generated forces and viscoelastic moduli in real time, showing ligand and cell density affect mechanical properties of HUVECs.

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn2+-releasing mechanism

The paper presents a cryo-EM structure of ZnT8 at low pH, suggesting protons disrupt Zn2+ coordination, aiding its release into the lumen.

Wild-type allele of TaHRC suppresses calcium-mediated plant immune response by hijacking TaCAXIP4 to trigger FHB susceptibility in wheat

This study identifies TaHRC as a susceptibility gene for FHB in wheat, showing it suppresses calcium-mediated immune responses by interacting with TaCAXIP4.

DeepTracer ID: De Novo Protein Identification from Cryo-EM Maps

DeepTracer-ID identifies proteins from cryo-EM maps without additional sequence information by combining DeepTracer modeling with AlphaFold2 predictions.

Dynamic Changes in Fecal Bacterial Microbiota of Dairy Cattle across the Production Line

This study characterizes fecal bacterial communities in dairy cattle across different management units, finding dynamic changes in diversity and composition.

Development and optimization of a Barley stripe mosaic virus (BSMV)-mediated gene editing system to improve Fusarium head blight (FHB) resistance in wheat

This paper develops a BSMV-mediated gene editing system for wheat to improve FHB resistance by editing the Fhb1 gene without requiring transformation.

Cooperative Allostery and Structural Dynamics of Streptavidin at Cryogenic- and Ambient-temperature

The paper presents two apo-streptavidin structures at different temperatures and reveals cooperative allostery through water-mediated interactions.

Prevalent uses and evolution of exonic regulatory sequences in the human genome

The paper investigates the prevalence and evolution of exonic regulatory sequences, finding that exonic TFBSs are common and may evolve into regulatory elements when non-exonic sequences are unavailable.

Single-cell transcriptomics elucidates in vitro reprogramming of human intestinal epithelium cultured in a physiodynamic gut-on-a-chip

This study uses single-cell transcriptomics to show that a gut-on-a-chip culture reprograms human intestinal epithelial cells to exhibit in vivo-like heterogeneity and physiological functions.

An ultrapotent neutralizing bispecific antibody with broad spectrum against SARS-CoV-2 variants

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

Host EPAC1 modulates rickettsial adhesion to vascular endothelial cells via regulation of ANXA2 Y23 phosphorylation

This study investigates how EPAC1 regulates rickettsial adhesion to endothelial cells by modulating ANXA2 Y23 phosphorylation, using in vivo models and FluidFM.

Withaferin A promotes white adipose browning and prevents obesity through sympathetic nerve-activated Prdm16-FATP1 axis

This study shows that Withaferin A promotes white adipose browning and prevents obesity by activating the Prdm16-FATP1 pathway via the sympathetic nervous system.

Structural insight into host plasma membrane association and assembly of HIV-1 Matrix protein

This study presents crystal structures of HIV-1 MA domain bound to IP6, revealing its binding mode and interaction with PIP2, providing insights into virion assembly.

Inhibition of HSP90 reversed STAT3 mediated muscle wasting induced by cancer cachexia

The paper shows that inhibiting HSP90 reduces STAT3-mediated muscle wasting in cancer cachexia by disrupting the HSP90/STAT3/FOXO1 axis.

Reproducibility of protein X-ray diffuse scattering and potential utility for modeling atomic displacement parameters

Profiles of Expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

Cell-type apoptosis in lung during SARS-CoV-2 infection

This study investigates cell-type apoptosis in lung tissues during SARS-CoV-2 infection, finding both intrinsic and extrinsic apoptotic pathways are activated, while some cell types remain refractory to infection.

Identification of four linear B-cell epitopes on the SARS-CoV-2 spike protein able to elicit neutralizing antibodies

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

Endothelial exosome plays functional role during rickettsial infection

This study investigates the role of Rickettsia-infected endothelial cell-derived exosomes in causing barrier dysfunction in brain microvascular endothelial cells, identifying miR-23a and miR-30b as key regulators.

Near-Physiological-Temperature Serial Femtosecond X-ray Crystallography Reveals Novel Conformations of SARS-CoV-2 Main Protease Active Site for Improved Drug Repurposing

The paper determines two apo structures of SARS-CoV-2 main protease at near-physiological temperature using SFX and uses molecular simulations to analyze inhibitor binding for drug repurposing.