BiochemistrybioRxiv
Structural basis of TRPV1 modulation by endogenous bioactive lipids
W. R. Arnold, A. S. Mancino, F. R. Moss…·Y. Cheng
This study identifies a lipid-binding pocket in TRPV1 and shows that its occupancy by phosphoinositides modulates channel activity, with lipid ejection triggering activation.
DOI 10.1038/s41594-024-01299-2