Y. Amano

Giant genes are rare but implicated in cell wall degradation by predatory bacteria

The paper identifies giant genes in predatory bacteria, showing they are associated with prey adhesion and cell wall degradation.

Essential role of an acidic endosomal environment in JAK3-mediated signal transduction

This study shows that acidic endosomal environments are essential for JAK3-mediated signal transduction and that IAVNs like chloroquine and monensin disrupt this process, affecting cytokine signaling and arthritis.

Methanotrophic Methanoperedens archaea host diverse and interacting extrachromosomal elements

The paper identifies and characterizes diverse extrachromosomal elements in Methanoperedens archaea, including mini-Borgs and viruses, and shows their genetic exchange and potential impact on archaeal activity.

RAID: Regression Analysis based Inductive DNA microarray for Precise Read-Across

RAID predicts in vivo gene expression from chemical structure or in vitro data, showing effectiveness in hepatotoxicity assessment.

A widespread group of large plasmids in methanotrophic Methanoperedens archaea

This paper identifies large plasmids in Methanoperedens archaea that are essential for their physiology and may be used to study and manipulate methane oxidation.

Fe(III)-dependent anaerobic methane-oxidizing activity in a deep underground borehole demonstrated by in-situ pressure groundwater incubation

The study demonstrates Fe(III)-dependent anaerobic methane oxidation in deep groundwater using in-situ pressure incubation, showing higher activity in 214-m deep samples compared to 249-m deep samples.

Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids

This study shows that appropriate tension sensitivity of α-catenin is essential for epithelial cells to form round spheroids through multicellular rearrangement.

The Chloroflexi supergroup is metabolically diverse and representatives have novel genes for non-photosynthesis based CO2 fixation

This study investigates the metabolic diversity of the Chloroflexi supergroup, revealing novel genes for non-photosynthesis based CO2 fixation and diverse metabolic capabilities across related phyla.

Patterns of gene content and co-occurrence constrain the evolutionary path toward animal association in CPR bacteria

This study examines gene content and co-occurrence patterns in CPR bacteria to understand their evolutionary transitions between environmental and animal-associated habitats.

Groundwater Elusimicrobia are metabolically diverse compared to gut microbiome Elusimicrobia and some have a novel nitrogenase paralog

The paper analyzes genomes of Elusimicrobia from various environments, finding groundwater-associated species show diverse metabolic capabilities and some encode novel nitrogenase paralogs.

Phosphorylation and dephosphorylation of Ser852 and Ser889 control clustering, localization, and function of PAR-3

This study shows that phosphorylation and dephosphorylation of PAR-3 at Ser852 and Ser889 regulate its clustering, localization, and function in cell polarity and junction formation.

Clades of huge phage from across Earth’s ecosystems

The paper identifies major clades of large phage genomes across diverse ecosystems and highlights their expanded genetic repertoires and potential functional roles.

Hydrogen-based metabolism - An ancestral trait in lineages sibling to the Cyanobacteria

This paper predicts the metabolisms of Margulisbacteria and Saganbacteria using genomic data and compares them to their phylogenetic neighbors, supporting the hypothesis that their ancestor used hydrogen metabolism and fermentation.