Circulating ACE2-expressing Exosomes Block SARS-CoV-2 Virus Infection as an Innate Antiviral Mechanism
L. El-Shennawy, A. D. Hoffmann, N. K. Dashzeveg, P. J. Mehl, Z. Yu, V. L. Tokars, V. Nicolaescu, C. Ostiguin, Y. Jia, L. Li, K. Furlong, C. Mao, J. Wysocki, D. Batlle, T. J. Hope, , H. Liu
The paper shows that ACE2-expressing exosomes in plasma block SARS-CoV-2 infection by competing with cellular ACE2, offering a new innate antiviral mechanism.
bioRxiv · Dec 3, 2020Immunology