High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension
T. Shinohara, J.-R. A. J. Moonen, Y. H. Chun, Y. C. Lee-Yow, K. Okamura, J. M. Szafron, J. Kaplan, A. Cao, L. Wang, S. Taylor, S. Isobe, M. Dong, W. Yang, K. Guo, B. D. Franco, , M. Rabinovitch
The paper shows high shear stress induces endothelial-mesenchymal transition and pulmonary arterial hypertension by reducing ERG expression, which can be mitigated by ERG replenishment.
bioRxiv · Feb 2, 2024Cell Biology