Cell BiologybioRxiv
Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence
C. H. Choy, G. Saffi, M. A. Gray…·R. J. Botelho
This study shows that PIKfyve inhibition causes lysosome coalescence, leading to fewer enlarged lysosomes, and that TFEB-mediated biosynthesis does not drive this swelling.
DOI 10.1242/jcs.213587