Author

C. Wallace

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:flow cytometry· 2

Frequent Co-Authors

A. J. Cutler· 2 shared D. B. Dunger· 2 shared D. B. Rainbow· 2 shared D. J. Smyth· 2 shared J. A. Todd· 2 shared L. S. Wicker· 2 shared M. L. Pekalski· 2 shared M. Mashar· 2 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. J. Cutler

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A disease-associated gene desert orchestrates macrophage inflammatory responses via ETS2

C. T. Stankey, C. Bourges, T. Turner-Stokes, A. P. Piedade, C. Palmer-Jones, I. Papa, M. Silva dos Santos, L. O. Randzavola, L. Speidel, E. C. Parkes, W. Edwards, A. P. Rochford, C. Murray, J. I. MacRae, P. Skoglund, , J. C. Lee

The paper identifies ETS2 as a master regulator of macrophage inflammatory responses linked to a disease-associated gene desert and shows how modulating this pathway could improve treatment of inflammatory diseases.

bioRxiv · May 5, 2023Immunology

Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

T. N. Hoang, E. G. Viox, A. A. Upadhyay, Z. Strongin, G. K. Tharp, M. Pino, R. Nchioua, M. Hirschenberger, M. Gagne, K. Nguyen, J. L. Harper, S. Marciano, A. K. Boddapati, K. L. Pellegrini, J. Tisoncik-Go, , M. Paiardini

This study shows that modulating type I interferon responses in rhesus macaques reduces SARS-CoV-2 viral load and inflammation, suggesting a potential therapeutic strategy for severe COVID-19.

bioRxiv · Oct 21, 2022Immunology

Cytoplasmic CPSF6 regulates HIV-1 capsid trafficking and infection in a cyclophilin A-dependent manner

Z. Zhong, J. Ning, E. A. Boggs, S. Jang, C. Wallace, C. Telmer, M. Bruchez, J. Ahn, A. Engelman, p. zhang, S. C. Watkins, Z. Ambrose

The paper shows CPSF6 and CypA interact to regulate HIV-1 capsid trafficking and infection by affecting capsid-CPSF6 complex formation and stability.

bioRxiv · Jun 5, 2020Microbiology

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

C. H. Choy, G. Saffi, M. A. Gray, C. Wallace, R. M. Dayam, Z.-Y. A. Ou, G. Lenk, R. Puertollano, S. C. Watkins, R. J. Botelho

This study shows that PIKfyve inhibition causes lysosome coalescence, leading to fewer enlarged lysosomes, and that TFEB-mediated biosynthesis does not drive this swelling.

bioRxiv · Apr 5, 2018Cell Biology

Cells With Treg-Specific FOXP3 Demethylation But Low CD25 Are Prevalent In Autoimmunity

R. C. Ferreira, H. Z. Simons, W. Thompson, D. B. Rainbow, X. Yang, A. J. Cutler, J. Oliveira, X. C. Dopico, D. J. Smyth, N. Savinykh, M. Mashar, T. Vyse, D. B. Dunger, H. Baxendale, A. Chandra, , M. L. Pekalski

The paper identifies CD25lowFOXP3+ T cells as a subset of regulatory T cells expanded in autoimmune diseases, characterized by FOXP3 demethylation and distinct functional features.

bioRxiv · May 5, 2017Immunology

Recent thymic emigrants produce antimicrobial IL-8, express complement receptors and are precursors of a tissue-homing Th8 lineage of memory cells

M. L. Pekalski, A. Rubio Garcia, R. C. Ferreira, D. B. Rainbow, D. J. Smyth, M. Mashar, J. Brady, N. Savinykh, X. Castro Dopico, S. Mahmood, S. Duley, H. E. Stevens, N. M. Walker, A. J. Cutler, F. Waldron-Lynch, , L. S. Wicker

The paper identifies CR2+ naive T cells as recent thymic emigrants that express antimicrobial IL-8 and complement receptors, and may become tissue-homing memory cells.

bioRxiv · Jun 17, 2016Immunology