Matías Fabregat

This study identifies polyamine-dependent tumor-adipose crosstalk as an early driver of fat wasting in cancer cachexia, linking polyamine metabolism to adipocyte lipolysis and poor patient survival.

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

This paper generates Ccdc28b mutant mice and finds they exhibit social behavioral defects and autism-like features, suggesting a link between CCDC28B and autism spectrum disorder beyond its role as a modifier of Bardet-Biedl syndrome.