Richard A. Anderson

This study identifies a role for nuclear phosphoinositides in regulating MDM2 stability and function through interactions with small heat shock proteins, offering a new therapeutic target in cancer.

This study shows that Star-PAP is regulated by phosphoinositides in response to stress through interactions with PITP/{beta}, PI kinases/phosphatases, and HSP27.

This study shows that PIPKIγ and HSP27 regulate NRF2 stability and function, promoting stress resistance and suggesting them as potential drug targets in cancer.

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

This study shows the Hira complex is essential for male pronucleus formation in mice and humans, with Cabin1 and Ubn1 playing critical roles, and demonstrates potential for IVF therapy.