Vincent L. Cryns

The paper identifies a PIPn-linked proteome in membrane-free regions, showing that PITP/β and PI4KIIα generate protein-PIPn complexes involved in metabolic and signaling pathways.

This study identifies a role for nuclear phosphoinositides in regulating MDM2 stability and function through interactions with small heat shock proteins, offering a new therapeutic target in cancer.

This study shows that Star-PAP is regulated by phosphoinositides in response to stress through interactions with PITP/{beta}, PI kinases/phosphatases, and HSP27.

This study shows that PIPKIγ and HSP27 regulate NRF2 stability and function, promoting stress resistance and suggesting them as potential drug targets in cancer.

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

This study shows that p85 loss enhances PI3K/Akt signaling through endosomal p110 activation via MAP4 and PI3P binding.