Author

N. Stephanopoulos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:DNA methylation· 4 Research Focus:cell type annotation· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

T. MacCulloch· 3 shared E. Poppleton· 2 shared H. Yan· 2 shared P. Sulc· 2 shared Y. Xu· 2 shared A. Buchberger· 1 shared A. Doherty· 1 shared A. Novacek· 1 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBioengineering

T. MacCulloch

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6 papers

Recent·Most cited

Site-specific arrangement and structure determination of minor groove binding molecules in self-assembled three-dimensional DNA crystals

C. R. Simmons, A. Buchberger, S. J. W. Henry, A. Novacek, N. E. Fahmi, T. MacCulloch, N. Stephanopoulos, H. Yan

This paper demonstrates the site-specific arrangement and structural determination of minor groove binding molecules in self-assembled DNA crystals using x-ray crystallography.

bioRxiv · Oct 10, 2023Bioengineering

Construction and reconfiguration of dynamic DNA origami assemblies with coiled-coil patches and patterns

T. Teng, J. Bernal, N. Stephanopoulos, C. Castro

This paper constructs dynamic DNA origami assemblies using coiled-coil peptides to create reconfigurable structures with tunable mechanical properties.

bioRxiv · Sep 23, 2023 · PreprintBioengineering

IgG-inspired, multivalent protein-DNA nanostructures for high-affinity, tunable, and reversible binding to biomolecular targets

R. Zheng, Y. Xu, A. Prasad, M. Liu, Z. Wan, J. Jiang, X. Zhou, R. M. Porter, M. Sample, E. Poppleton, J. Procyk, H. Liu, A. Doherty, P. Nyaupane, Y. Li, , N. Stephanopoulos

This paper designs and tests a DNA-based synthetic antibody (nano-synbody) that binds SARS-CoV-2 spike proteins with high affinity and reversibility through multivalency.

bioRxiv · Sep 18, 2023 · PreprintBioengineering

DNA Nanostructure-Guided Assembly of Proteins into Programmable Shapes

Q. Lu, Y. Xu, E. Poppleton, K. Zhou, P. Sulc, N. Stephanopoulos, Y. Ke

This paper describes a method using DNA origami to guide the assembly of protein-DNA conjugates into programmable nanostructures with controlled stoichiometry and geometry.

bioRxiv · Aug 7, 2023Bioengineering

Using dynamic biomaterials to study the temporal role of osteogenic growth peptide during osteogenesis

F. M. Fumasi, T. MacCulloch, J. Bernal-Chanchavac, N. Stephanopoulos, J. L. Holloway

This study develops a DNA-based hydrogel platform to control the temporal presentation of biomolecules, showing delayed osteogenic growth peptide (OGP) delivery increases alkaline phosphatase activity during osteogenesis.

bioRxiv · Jul 19, 2023 · PreprintBioengineering

Uncovering temporally sensitive targeting motifs for traumatic brain injury via phage display

B. I. Martinez, G. A. Mousa, K. Fleck, T. MacCulloch, C. W. Diehnelt, N. Stephanopoulos, S. E. Stabenfeldt

This study identifies temporally specific targeting motifs for traumatic brain injury using phage display, revealing distinct epitopes associated with acute and subacute injury phases.

bioRxiv · Jun 16, 2020 · PreprintBioengineering