Scott C. Weaver

This study identifies the molecular basis of chikungunya virus recognition of the mosquito-specific receptor Lachesin using cryo-EM structures and shows a Lachesin polymorphism that blocks virus entry.

This study identifies Lachesin as a mosquito receptor for multiple arthritogenic alphaviruses using CRISPR screening in Aedes albopictus cells.

This paper introduces a computational pipeline for antigen discovery that uses filtering and machine learning to identify conserved neutralizing epitopes in viruses like SARS-CoV-2 and RVFV.

The paper identifies pathogens in high-altitude windborne mosquitoes, showing they are infectious and capable of spreading diseases over long distances.

This study examines how mosquito genetic background and associated microbiomes influence Zika virus infection outcomes in Aedes aegypti, revealing line-specific microbiome responses to viral exposure.

This study identifies three HS-binding sites on EEEV E2 glycoprotein that contribute to both HS and protein receptor-dependent infection, affecting disease and mosquito infectivity.

This study uses rhesus macaques to model MAYV infection and transmission to Aedes aegypti mosquitoes, finding short viremia, low transmission rates, and limited mosquito infectivity.

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.

This study identifies AePer50, a gene upregulated during dehydration in Aedes aegypti, as critical for midgut infection of arboviruses under low humidity conditions.

This study evaluates an insect-based chimeric virus vaccine against Chikungunya fever, showing rapid and durable protection in macaques.

The paper shows that prior immunity to dengue and Zika viruses reduces yellow fever viremia, limiting mosquito infection and urban transmission risk.

This study develops murine models of Ilheus virus infection and shows Aedes mosquitoes are highly susceptible, suggesting ILHV is poised for emergence in the neotropics.

This study examines seroprevalence of Madariaga and Venezuelan equine encephalitis viruses in rodents across Eastern and Western Panama, revealing spatial and species-specific patterns.

Tiled-ClickSeq enables complete SARS-CoV-2 genome sequencing with detection of RNA recombination and minority variants in a single assay.