Juan J. Tena

The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.

This study presents a multi-omic atlas of the siphonophore Physalia utriculus, revealing the regulatory mechanisms of colonial division of labour and the molecular basis of venom activity.

The paper uses single-cell multiomics to identify key regulatory nodes and cis-regulatory elements in zebrafish eye development.

This study presents a single-cell multiomics atlas of zebrafish spermatogenesis, identifying key transcriptional states, DNA methylation changes, and chromatin accessibility patterns involved in male germline formation.

The paper identifies ancestral dorsal-ventral patterning mechanisms in fish fins and shows evolutionary innovations in their regulation.

This study identifies neotenic transcriptomic features in the adult turquoise killifish brain, showing embryonic gene expression patterns and their potential role in maintaining high proliferation and metabolic rates.

This study investigates DNA methylation and gene expression changes during flatfish metamorphosis using multi-omics data from turbot brain at three stages.

This study examines DNA methylation changes in migrating and non-migrating eyes of turbot during metamorphosis, linking methylation patterns to gene expression and visual system remodeling.

This study presents chromosome-level genome assemblies of two hemichordates to infer deuterostome ancestral chromosomal architecture and lineage-specific modifications.

The paper constructs a single-cell RNA-seq atlas of amphioxus neurula stage to investigate the evolutionary origins of vertebrate head mesoderm.

This study identifies FKH-8 as a master regulator of the primary ciliome in C. elegans, showing its role in gene expression, cilium morphology, and sensory behaviors.

The paper compares 3D genome structures between neural retina and RPE to identify tissue-specific cis-regulatory interactions at retinal disease loci.

This study investigates the effects of retinoic acid signaling on the epigenome and chromatin architecture during zebrafish embryonic development using multi-omics approaches.

This study identifies cis-regulatory elements and non-coding variants associated with North Carolina macular dystrophy using multi-omics and enhancer assays.

This study shows that CTCF knockout in zebrafish disrupts chromatin structure and gene regulation during development, affecting thousands of genes and developmental programs.

The paper identifies a regulatory region near the IL33 gene that influences asthma risk through allele-specific expression and OCT-1 binding.

The paper identifies cis-regulatory elements in the zebrafish and human pancreas, revealing disease-related enhancers that affect gene expression and contribute to pancreatic disorders.