Joshua Eric Elias

This paper introduces a platform called ProteoParcel that combines whole-cell imaging with single-cell mass spectrometry proteomics for breast cancer cells.

The paper presents a multimodal perturbation atlas using CRISPR knockouts in A549 cells, combining microscopy, phase imaging, and scRNA-seq to assess phenotypic resolution.

The paper shows that cell size affects mRNA concentrations, driving proteome changes through transcriptional regulation.

This study shows that cell enlargement drives proteome remodeling and shortens replicative lifespan in yeast, independent of known aging factors.

The paper introduces optogenetic proximity labeling to map mitochondrial surface proteomes and ribosome pools, revealing Miro1's role in spatially organizing mitochondrial protein biogenesis.

This study uses a dengue replicon model to show how host pathways are rewired to support persistent RNA replication without stress responses.

The paper identifies ADAR1 as a host factor that restricts poliovirus infection by editing viral RNA to disrupt translation initiation and introduce a coding error.

The paper shows that mosquito salivary gland and sporozoite gene expression cycles with the day-night rhythm, affecting malaria transmission.

The paper maps subcellular localization of human proteins and shows proteome remodeling during viral infection by combining organelle immuno-capture with mass spectrometry.

Rapid QC-MS provides an automated dashboard for real-time quality control of LC-MS/MS data, improving efficiency and accuracy in untargeted workflows.

This study uses single-cell transcriptomics and proteomics to analyze Vaccinia virus infection dynamics and host response heterogeneity in HeLa and fibroblast cells.

This paper introduces a high-throughput stool proteomic pipeline, SHT-Pro, and demonstrates its application in classifying dietary interventions based on proteomic profiles with up to 89% accuracy.

This study shows HIPK4 is essential for spermiogenesis and male fertility in mice, with defects in sperm head morphology and fertility.

The paper shows that plasma from exercising mice reduces brain inflammation and improves memory, with clusterin as a key anti-inflammatory factor also elevated in human exercisers.

This study quantifies variability in host proteins and bacterial taxa in stool samples from healthy individuals, showing greater inter-subject variation than temporal or technical variation.

This study identifies novel MHC-I antigens specific to dengue virus infection using an immuno-proteomics approach, revealing ligands associated with distinct HLA haplotypes and T-cell recognition.

The paper introduces TagGraph, a software tool that improves PTM identification in proteomics by addressing search space size and identification accuracy challenges, resulting in tripled confident identifications and expanded knowledge of PTM sites.