Yasuko Orba

This study uses cryo-ET to analyze native, active SARS-CoV-2 virions, revealing a transient open-trimer prefusion state and hidden spike flexibility with implications for vaccine design.

This study shows favipiravir suppresses OROV replication and disease in hamsters, preventing neuroinvasion and pathogenic host responses through transcriptomic analysis.

This study develops a reverse genetics system for Yezo virus to investigate the role of its glycoprotein N-terminal region in replication across mammalian and tick hosts.

This study shows IL-34 promotes DAM-like microglial activation and protects against WNV infection in cell culture and mice.

This study evaluates AddaS03 as an adjuvant for a WNV subunit vaccine, showing it elicits higher neutralizing antibody titers and provides full protection in mice compared to Alhydrogel.

This paper develops a CPER-based reverse genetics system for rabies virus, enabling the generation of recombinant viruses with various genetic modifications.

This study develops a luciferase-based biosensor to detect and quantify dsRNA from various viral infections, showing broad-spectrum reactivity and utility in assessing antiviral compounds.

This study identifies and characterizes two nearly complete genomes of pigeon gammacoronaviruses, supporting their classification as a new species within the Igacovirus subgenus.

The paper identifies site-specific glycan compositions of SARS-CoV-2 spike protein using mass spectrometry and lectin microarray, revealing key glycan structures relevant to vaccine design.

LIGHTHOUSE identifies novel therapeutics for diseases including cancer, bacterial infections, and COVID-19 using a graph-based deep learning approach without requiring 3D structural data.