Vasanth Siruvallur Murali

This study shows that branched actin-driven membrane protrusions (BAMPs) enhance oncogenic KRAS signaling by amplifying upstream regulators and promoting cell proliferation through merlin inactivation.

This study identifies fascin-1's role in promoting anchorage-independent proliferation through a novel signaling complex called PASS, which drives Rac1/PAK/JNK signaling in cancer cells.

This study identifies RhoA activation as a driver of glucose uptake and proliferation in MAPK inhibitor-resistant melanoma cells through ROCK-mediated IRS1 and PI3K pathway activation.

This paper shows that a Rac1 mutation drives melanoma proliferation independently of MAPK signaling by forming a mechanosensitive actin network that inactivates the tumor suppressor NF2/Merlin.