Jianhua Zhang

This study shows ripasudil reduces tau pathology and improves mitochondrial function in AD models.

The paper demonstrates that hiPSC-derived cardiac progenitor cells injected into swine hearts after MI form grafts that improve stress-induced contractile reserve without causing arrhythmias.

This study shows that mitochondrial-containing sEVs from MDRCs activate and polarize Th17 and Th2 cells in asthma, contributing to airway inflammation.

This study identifies Dgat2 as a key modulator linking amyloid pathology, lipid dysregulation, and neuroinflammation in Alzheimer's disease across Drosophila and mouse models.

This study shows that elevated O-GlcNAcylation reduces mitophagy in astrocytes and alters glia homeostasis in the dentate gyrus.

This study shows that CtsD regulates bone turnover through distinct autophagy mechanisms in osteoblasts and osteoclasts, suggesting it as a therapeutic target for bone mass maintenance.

This study examines how allogeneic stem cell transplant affects subclonal evolution in chronic lymphocytic leukemia, identifying cellular homogeneity as a biomarker for immune response.

This study examines the effects of late-life alcohol exposure on spatial memory and TFEB activity in young and aged mice, finding that aging has a greater impact than alcohol.

This study finds that aging baboons show sex-specific declines in prefrontal cortex mitochondrial bioenergetics, with males experiencing greater ETC activity loss and a link between walking speed and respiration in males.

This study examines the acute effects of increasing protein O-GlcNAcylation in mice brains using OGA inhibitor Thiamet G, identifying transcriptome changes opposite to those seen in Alzheimer's disease.

This study investigates whether enhancing cathepsin D or disrupting ZKSCAN3 in the CNS can reduce α-synuclein aggregation and dopaminergic neurodegeneration, but finds no significant effect.