Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
Jyoti Batra, Magdalena Rutkowska, Yuan Zhou…·Nevan J. Krogan
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Gladstone InstitutesORCID 0000-0002-2335-0607Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
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Jyoti Batra, Magdalena Rutkowska, Yuan Zhou…·Nevan J. Krogan
Ségolène Gracias, Elodie Le Seac’h, Samuel Donaire-Carpio…·Nolwenn Jouvenet
This study investigates BANAL-236, a SARS-CoV-2-related bat virus, showing it can use human entry factors and evade human innate immunity, suggesting potential for zoonotic spillover.
Grace Uwase, Priya Luthra, Olivia A. Vogel…·Gaya K. Amarasinghe
This study identifies and characterizes the NNLNS motif in Ebola virus VP35 that mediates MIB2 binding, inhibiting IFN production and affecting viral RNA synthesis.
CJ San Felipe, Jyoti Batra, Monita Muralidharan…·James S. Fraser
This study develops a biophysical model to show how lipid binding and mutations affect Orf9b's conformational equilibrium and its interaction with Tom70, influencing interferon suppression.
Mir Mubashir Khalid, Irene P. Chen, Frank W. Soveg…·Mélanie Ott
This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.
Mehdi Bouhaddou, Ann‐Kathrin Reuschl, Benjamin J. Polacco…·Nevan J. Krogan
The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.
David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou…·Natalia Jura
Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.