Ségolène Gracias

This study identifies POWV NS5 as a central inhibitor of cytokine signaling by targeting TYK2 and suppressing multiple antiviral pathways.

This study identifies the nuclear localization and interactome of TBEV NS5 protein, revealing its role in modulating viral replication through interactions with nuclear factors.

This study investigates BANAL-236, a SARS-CoV-2-related bat virus, showing it can use human entry factors and evade human innate immunity, suggesting potential for zoonotic spillover.

This study identifies IFI6 as a key antiviral effector mediating type I and III interferon restriction of tick-borne orthoflaviviruses in human cells and mice.

This paper modifies a measles vaccine by removing a viral protein to create a cancer immunotherapy that activates the immune system via RIG-I signaling, leading to tumor regression in multiple models.

This study evaluates the phenotypic susceptibility of HIV-1 non-group M strains to Maraviroc, showing variability linked to tropism and highlighting the need for additional parameters beyond IC50 values.

This study identifies a mechanism by which tick-borne flaviviruses inhibit interferon signaling by targeting TYK2 catalytic activity through their NS5 protein.