Brandon F. Keele

The paper identifies two distinct phases of immune system changes in ART-suppressed HIV infection using single-cell transcriptomics and proteomics in rhesus macaques.

AAV-delivered broadly neutralizing antibodies provide durable protection against SIV challenge in rhesus macaques, while ADCC-only antibodies do not.

This study shows that caloric restriction in SIV-infected rhesus macaques reduces acute viremia, dampens inflammation, and improves metabolic function, but does not affect viral persistence.

This study uses a barcoded SIV infection model to analyze the dissemination bottleneck in rhesus macaques, finding anatomical heterogeneity contributes most to early viral spread variability.

This study shows that IL-6 restricts pre-thymic T cell lineage commitment in SIV-infected rhesus macaques, contributing to loss of viral control.

This study shows CD8α+ cells suppress SIV replication without immune escape in post-treatment controllers, using a macaque model and barcoded viral sequencing.

This study identifies the origin and dynamics of viral rebound in SIV-infected macaques after ART discontinuation, showing local tissue replication and systemic expansion of clonal lineages.

This study shows that retaining CD8+ T cells in lymphoid tissues during ART interruption does not prevent SIV rebound, even with immunomodulators.

This study shows that delivering Env-specific antibodies via AAV prevents SIV rebound in macaques after stopping ART.

TGF-β blockade with galunisertib reverses SIV latency, reduces viral reservoirs, and enhances immune responses in ART-treated macaques without systemic inflammation.

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

The paper identifies large T-cell clones producing infectious HIV-1 virus as a source of non-suppressible viremia despite ART adherence and no drug resistance.