Christine M. Fennessey

AAV-delivered broadly neutralizing antibodies provide durable protection against SIV challenge in rhesus macaques, while ADCC-only antibodies do not.

This study shows that caloric restriction in SIV-infected rhesus macaques reduces acute viremia, dampens inflammation, and improves metabolic function, but does not affect viral persistence.

This study uses a barcoded SIV infection model to analyze the dissemination bottleneck in rhesus macaques, finding anatomical heterogeneity contributes most to early viral spread variability.

This study identifies the origin and dynamics of viral rebound in SIV-infected macaques after ART discontinuation, showing local tissue replication and systemic expansion of clonal lineages.

This study shows that delivering Env-specific antibodies via AAV prevents SIV rebound in macaques after stopping ART.

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.