Jeffrey D. Lifson

This paper develops a bispecific biologic that effectively reactivates HIV-1 and SIV latency in multiple models with minimal off-target effects.

The paper identifies two distinct phases of immune system changes in ART-suppressed HIV infection using single-cell transcriptomics and proteomics in rhesus macaques.

This study identifies the origin and dynamics of viral rebound in SIV-infected macaques after ART discontinuation, showing local tissue replication and systemic expansion of clonal lineages.

This study shows combining a RhCMV/SIV vaccine with neutralizing antibodies enhances protection against SIV challenge in rhesus macaques.

This study shows that delivering Env-specific antibodies via AAV prevents SIV rebound in macaques after stopping ART.

This study uses single-cell RNA sequencing to analyze microglia and macrophages in rhesus macaques during acute SIV infection, revealing changes in cell clusters and gene expression linked to inflammation and neurodegeneration.

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

The paper identifies CCR7+ CD4 T cells in rhesus brain and border tissues, showing their decline during chronic SIV-induced neuroinflammation and their role in CNS immune surveillance.

This study investigates CD4 T cell responses in the CNS during SIV infection in rhesus macaques, revealing their role in viral persistence and immune activation despite ART.

The paper identifies an IL-15 response signature in vaccinated rhesus macaques that correlates with protection against SIV challenge following RhCMV/SIV vaccination.