BiophysicsMolecular CellPeer-reviewed
Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN Domain
Gabriel I. Small, Olga Fedorova, Paul Dominic B. Olinares…·Elizabeth A. Campbell
This study determines cryo-EM structures of SARS-CoV-2 NiRAN domain catalytic intermediates, revealing structural mechanisms for NMPylation and deRNAylation/capping, and explaining substrate preference for capping.