Joshua Chandanani

This study identifies MtvS1 and MtvS2 as regulators of the Francisella type V-A CRISPR-Cas system and shows they interact with RNA polymerase to modulate gene expression.

The paper shows that KorB, a DNA-sliding clamp, switches to a repressor role with KorA to mediate long-range gene silencing on plasmid RK2.

This study determines cryo-EM structures of SARS-CoV-2 NiRAN domain catalytic intermediates, revealing structural mechanisms for NMPylation and deRNAylation/capping, and explaining substrate preference for capping.