Author
The Francis Crick InstituteORCID 0000-0001-8660-2528Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Chrislaine Martinez, Zahie Taha, Christine R. Collins…·Michael J. Blackman
This study develops an in vitro system to study SERA6 maturation and validates inhibitors that block malaria parasite egress.
Roman O Fedoryshchak, Karim El-Bouri, Dhira Joshi…·Richard Treisman
The paper identifies 4E-BP and p70 S6K as substrates of PP1-Neurabin/Spinophilin holoenzymes and shows that PDZ domain interactions, not PP1 groove remodeling, determine substrate specificity.
Hugo Belda, David Bradley, Evangelos Christodoulou…·Moritz Treeck
This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.
M. Teresa Bertran, Robert Walmsley, T. F. M. Cummings…·Louise J. Walport
The paper develops cyclic peptide modulators of PADI4 and reveals their mechanism of action and cellular activity.
Alžběta Roeselová, Sarah Maslen, Santosh Shivakumaraswamy…·David Balchin
The paper investigates how chaperones coordinate during cotranslational protein folding in bacteria, showing they create a protected space for maturation without destabilizing intermediates.