Ilia Voskoboinik

This study shows that Cas13 forms phase-separated RNA condensates to enhance target RNA accessibility and cleavage efficiency in both bacterial and mammalian cells.

This paper introduces CRISPR-PspCas13b as a method to systematically silence oncogenic fusion transcripts, showing effectiveness against drug-resistant cancer drivers.

This study shows acidic pH inhibits perforin pore formation, reducing immune cell killing of target cells in solid tumors.

This study designs CRISPR-Cas13b crRNAs with single-base precision to silence oncogenic gene fusions, enhancing targeting efficacy and selectivity.

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.