Author

Adrian W. Hodel

Peter MacCallum Cancer CentreORCID 0000-0003-0282-1200Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:bacteria (other)· 1 Assay:CRISPR screen· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Ilia VoskoboinikiD· 3 shared Bart W. HoogenboomiD· 2 shared Joseph A. TrapaniiD· 2 shared Bradley A. SpiceriD· 1 shared Carolyn ShembreyiD· 1 shared Charles Bayly-JonesiD· 1 shared Christopher J. LuptoniD· 1 shared Emma SiereckiiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMolecular Biology

Ilia VoskoboinikORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMay 13, 2026

Phase-Separated RNA Condensates Govern Cas13 Target Accessibility and Cleavage

Gurjeet Jagjeet Singh, Wenxin Hu, Carolyn Shembrey…·Mohamed Fareh

This study shows that Cas13 forms phase-separated RNA condensates to enhance target RNA accessibility and cleavage efficiency in both bacterial and mammalian cells.

DOI 10.64898/2026.05.12.724747

humanbacteria (other)

𝕏 PostBluesky

ImmunologyEMBO ReportsPeer-reviewedJan 9, 2025

Acidic pH attenuates immune killing through inactivation of perforin

Adrian W. Hodel, Jesse A. Rudd-Schmidt, Tahereh Noori…·Ilia Voskoboinik

This study shows acidic pH inhibits perforin pore formation, reducing immune cell killing of target cells in solid tumors.

15 citationstop 4%

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivPreprintMar 17, 2019

The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification.

Siew Siew Pang, Charles Bayly-Jones, Mazdak Radjainia…·James C. Whisstock

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.

DOI 10.1101/580712

cryo-EMexperimental assay

𝕏 PostBluesky