Author

Charles Bayly-Jones

Monash UniversityORCID 0000-0002-7573-7715Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:cryo-EM· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

James C. WhisstockiD· 2 shared Adrian W. HodeliD· 1 shared Anderly C. ChüehiD· 1 shared Andrew M. EllisdoniD· 1 shared Bao V. NguyeniD· 1 shared Bart W. HoogenboomiD· 1 shared Bradley A. SpiceriD· 1 shared Changyuan HuiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

James C. WhisstockORCID

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3 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedFeb 21, 2025

Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer

Xue Yang, Xiuquan Ma, Tianyue Zhao…·Roger J. Daly

This study identifies a novel feed-forward signalling axis between PEAK1 and CAMK2 in TNBC, showing that targeting CAMK2 can inhibit PEAK1-driven oncogenic processes.

10 citations

humanproteomics

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BioinformaticsPLoS Computational BiologyPeer-reviewedMar 25, 2022

Mining folded proteomes in the era of accurate structure prediction

Charles Bayly-Jones, James C. Whisstock

The paper uses fold recognition algorithms to mine the AlphaFold structure database for novel protein family members and functional insights.

16 citations

protein structurestatistical model

𝕏 PostBluesky

BiochemistrybioRxivPreprintMar 17, 2019

The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification.

Siew Siew Pang, Charles Bayly-Jones, Mazdak Radjainia…·James C. Whisstock

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.

DOI 10.1101/580712

cryo-EMexperimental assay

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