Bart W. Hoogenboom

This study shows PARP inhibitors reduce PARP1's DNA binding affinity by causing conformational changes independent of DNA, explaining similar cellular toxicities despite varying trapping potencies.

This study shows that polymyxin B lethality requires energy-dependent outer membrane disruption and depends on metabolic activity and LPS synthesis.

This study shows acidic pH inhibits perforin pore formation, reducing immune cell killing of target cells in solid tumors.

This paper introduces a Co2+-mediated adsorption method for DNA on mica to improve AFM imaging resolution by reducing salt precipitation compared to Ni2+.

The paper uses atomic force microscopy to study how MAC pores in E. coli lead to mechanical destabilization of the cell envelope, causing lysis through inner membrane permeation.

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.