Nathalia Romanelli Vicente Dragano

This study shows astrocytic AMPK links metabolic signals to hypothalamic circadian timing by regulating phosphoproteome organization and behavior.

This study compares TRα and TRβ knockout mice with DNA-binding-deficient mutants to show noncanonical TR signaling contributes to physiological functions beyond canonical genomic pathways.

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.