Satoru Takahashi

The paper examines NOTCH1 expression changes in human retinal progenitor cells and links them to chromatin remodeling using single-cell RNA-seq and ATAC-seq data.

The paper introduces GT-SPARCL, a genetic method for low-density neuronal labeling in mice, and applies it to reveal morphological subtypes of AVP neurons in the SCN.

TSUMUGI identifies gene networks driven by phenotypes using IMPC knockout mouse data to facilitate hypothesis generation for complex phenotypes.

The paper traces individual PGC clones in mice to show early stochastic bottlenecks shape clonal contributions and reproductive success.

This study identifies Muc6-expressing isthmus progenitors as key contributors to gastric regeneration and metaplasia through myeloid-mesenchymal interactions.

The paper identifies Dusp13 and Dusp27 as MYOD target genes that regulate muscle stem cell transition from proliferation to differentiation during myogenesis.

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

This study shows that Max gene disruption in germ cells leads to meiotic onset but results in apoptosis due to stalled meiotic progression.

The paper uses engineered human myoblasts to show that D4Z4 heterochromatin disruption and DUX4 network activation are key in FSHD.

This paper develops a chemogenetic method to selectively activate mGlu1 receptors in brain tissue using a palladium complex and a mutant receptor, demonstrating its role in synaptic plasticity.

This paper introduces DAJIN, a machine learning-assisted long-read sequencing method for comprehensive multiplex genotyping of genome editing outcomes, including intended and unintended mutations.

This study identifies MAST4's role in regulating DLX3 and stem cell maintenance in mouse incisor development, leading to Amelogenesis Imperfecta.

This study identifies EXOC1's role in regulating pseudopod formation in spermatogonia and syncytium formation in spermatocytes in mice, highlighting its interaction with Rac1 and SNAP23/STX2.

This study shows the Lin28a/let-7 pathway regulates Hox gene expression during axial patterning by modulating Polycomb complex occupancy in vertebrates.

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.