Author

Lothar Esser

National Cancer InstituteORCID 0000-0002-8680-6851Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:cryo-EM· 1 Organism:zebrafish· 1

Frequent Co-Authors

Di XiaiD· 2 shared Abraham J. MortoniD· 1 shared Alexander J. SodtiD· 1 shared Chao-Ming HsiehiD· 1 shared Emily Andersen· 1 shared Eric RosenbergiD· 1 shared Erin Gladu· 1 shared Fei Zhou· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Di XiaORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMay 30, 2026

Functional Implications of the Conformational Landscape of a Multidrug Transporter Revealed by Structures of Zebrafish Abcb4

Jingyu Zhan, Chao-Ming Hsieh, Lothar Esser…·Di Xia

This study reveals the conformational dynamics of zebrafish Abcb4 using cryo-EM, showing its open-and-close motion and substrate-binding flexibility, which may explain its polyspecificity.

1 citation

zebrafishcryo-EM

𝕏 PostBluesky

BiochemistryPLoS ONEPeer-reviewedApr 4, 2024

Point mutations in Arf1 reveal cooperative effects of the N-terminal region and myristate for GTPase-activating protein catalytic activity

Eric Rosenberg, Xiaoying Jian, Olivier Soubias…·Paul A. Randazzo

The paper investigates how point mutations in Arf1 affect its interaction with GAPs, revealing cooperative effects between the N-terminal region and myristate on catalytic activity.

1 citation

experimental assayprotein folding & dynamics

𝕏 PostBluesky