Hanneke Okkenhaug

This study shows that aged mice have reduced accumulation of small antigens in B cell follicles, potentially affecting vaccine responses.

This study shows that senescent human cells secrete misfolded proteins via the endo-lysosomal system, driven by DNAJC5 and reduced intracellular proteostasis.

This paper demonstrates a cytosine base editor that enables efficient and durable multiplexed gene knockout in iPSCs with minimal p53 activation and reduced DNA damage.

This study shows DDX1 promotes B-cell proliferation in germinal centres by enhancing mRNA translation through tRNA ligase activity, crucial for affinity maturation.

This study shows that Nlrp5-null oocytes have reduced DNMT3L and impaired de novo methylation, leading to imprinting disorders and developmental issues.

The paper develops cyclic peptide modulators of PADI4 and reveals their mechanism of action and cellular activity.

This study shows that maternal SMARCA5 is essential for major ZGA in mouse embryos by regulating promoter and distal regulatory region accessibility and nucleosome positioning.

This study shows that satellite repeat transcripts in mouse ESCs drive heterochromatin condensates, which are crucial for chromosome stability and nuclear organization.

This paper introduces a method to rejuvenate human fibroblasts by transient reprogramming to the maturation phase of iPSCs, followed by recovery of fibroblast identity, resulting in significant rejuvenation of transcriptome, epigenome, and functional markers.

This study shows that BAP1/ASXL complex modulation is essential for triggering EMT in trophoblast differentiation and invasion, with conserved function in mouse and human.

The paper shows that MSK-mediated phosphorylation of histone H3 at serine 28 couples MAPK signaling with chromatin remodelling and immediate early gene expression to induce pro-hypertrophic cardiac transcriptional responses.

This study identifies a neuronal thermostat mechanism in C. elegans that coordinates membrane fluidity across tissues in response to temperature changes.