Sean P. J. Whelan

This study identifies TMEM106B as an alternative receptor for SARS-CoV-2 S-E484D variant entry, independent of ACE2, in airway-derived cell models.

The paper identifies CD164 as an endolysosomal receptor for clade A New World arenaviruses, expanding the receptor switching paradigm observed in Old World arenaviruses.

The paper develops and tests new inhibitors of TMPRSS2 to block replication of SARS-CoV-2 and H1N1 influenza virus.

This study shows that Omicron variant-matched boosters after prototype mRNA vaccines induce cross-neutralizing antibodies against SARS-CoV-2 and sarbecoviruses by imprinting prior immune responses.

This paper shows LCMV spreads between cells via tunnelling nanotube-like structures, bypassing extracellular transmission.

This study identifies potassium ion flux as a third requirement for LCMV entry, showing it facilitates uncoating by modulating NP/Z interactions.

The paper determines the structure of infectious VSV particles using cryo-EM and computational classification, revealing the organization of the RNP and matrix proteins in the viral shaft and tip.

The paper designs and characterizes trivalent miniprotein binders that neutralize SARS-CoV-2 variants with low pM IC50 values and provide prophylactic and therapeutic protection in mice.

This study develops a replication-competent VSV-based vaccine against SARS-CoV-2 that elicits neutralizing antibodies and protects mice from viral infection and lung inflammation.

This paper presents the structure of the rabies virus polymerase complex determined by electron cryo-microscopy, revealing its pre-initiation conformation and differences from elongation states.

The paper reports the structure of vesicular stomatitis virus L protein in complex with its phosphoprotein cofactor, revealing how P induces a closed conformation for RNA synthesis.