William Wan

The paper characterizes VP40 mutants to understand their subcellular trafficking and assembly in Ebola virus using confocal microscopy and fluorescent tags.

Automated cryogenic plasma-focused ion beam milling and cryo-electron tomography of Chlamydomonas reinhardtii yield 1,829 annotated cellular tomograms and sub-nanometer in situ structures of six macromolecular complexes.

TOMOMAN streamlines cryo-ET data processing by integrating tools for interoperability, metadata management, and collaborative data sharing.

The paper introduces an algorithm to improve CTF estimation in cryo-ET tilt-series data by using tilt-series alignment parameters to account for specimen geometry, enhancing resolution of subtomogram averages.

This study uses cryo-electron tomography to reveal the structure of the intracellular Ebola virus nucleocapsid, identifying a new outer layer of NP complexed with VP35 and conserved assembly interfaces.

STOPGAP is an open-source tool for subtomogram averaging in cryo-ET data to identify, localize, and classify molecular structures.

This paper introduces a fast multi-position tomographic acquisition method for subtomogram averaging, achieving sub-nanometer resolution in situ.